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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC2 All Species: 53.33
Human Site: Y90 Identified Species: 73.33
UniProt: P06493 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06493 NP_001777.1 297 34081 Y90 L S M D L K K Y L D S I P P G
Chimpanzee Pan troglodytes XP_001164618 264 30384 V69 N I V S L Q D V L M Q D S R L
Rhesus Macaque Macaca mulatta XP_001095798 297 34077 Y90 L S M D L K K Y L D S I P P G
Dog Lupus familis XP_849450 297 34047 Y90 L S M D L K K Y L D S I P P G
Cat Felis silvestris
Mouse Mus musculus P11440 297 34088 Y90 L S M D L K K Y L D S I P P G
Rat Rattus norvegicus P39951 297 34116 Y90 L S M D L K K Y L D S I P P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509674 303 34737 Y90 L S M D L K K Y L D S I P P G
Chicken Gallus gallus P13863 303 34670 Y90 L S M D L K K Y L D T I P S G
Frog Xenopus laevis P24033 302 34513 Y90 L S M D L K K Y L D S I P S G
Zebra Danio Brachydanio rerio NP_997729 302 34539 Y90 L S M D L K K Y L D S I P S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23572 297 34420 Y90 L S M D L K K Y M D S L P V D
Honey Bee Apis mellifera XP_393093 585 68394 Y377 L T M D L K K Y M D N L G T G
Nematode Worm Caenorhab. elegans P34556 332 38277 Y108 L S F D L K R Y M D Q L G K D
Sea Urchin Strong. purpuratus XP_781415 301 34665 Y90 L T M D L K K Y M E S L K G K
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 F90 L D L D L K K F M D S C P E F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 H90 L D L D L K K H M D S T P D F
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 Y98 L D L D L K R Y M E G I P K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.5 99.3 98.6 N.A. 96.3 96.9 N.A. 95.3 90.4 84.7 81.4 N.A. 71.3 36.2 58.4 70.1
Protein Similarity: 100 88.8 99.6 99.6 N.A. 98.6 98.9 N.A. 96.6 94.3 93.3 91.7 N.A. 83.8 42.2 72.8 86.7
P-Site Identity: 100 13.3 100 100 N.A. 100 100 N.A. 100 86.6 93.3 93.3 N.A. 73.3 60 46.6 53.3
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 100 93.3 93.3 93.3 N.A. 86.6 86.6 66.6 80
Percent
Protein Identity: N.A. 63.3 N.A. 64.9 59 N.A.
Protein Similarity: N.A. 78.7 N.A. 79.4 76.5 N.A.
P-Site Identity: N.A. 53.3 N.A. 53.3 46.6 N.A.
P-Site Similarity: N.A. 73.3 N.A. 73.3 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % C
% Asp: 0 18 0 95 0 0 6 0 0 83 0 6 0 6 18 % D
% Glu: 0 0 0 0 0 0 0 0 0 12 0 0 0 6 0 % E
% Phe: 0 0 6 0 0 0 0 6 0 0 0 0 0 0 12 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 6 0 12 6 59 % G
% His: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % H
% Ile: 0 6 0 0 0 0 0 0 0 0 0 59 0 0 0 % I
% Lys: 0 0 0 0 0 95 83 0 0 0 0 0 6 12 6 % K
% Leu: 95 0 18 0 100 0 0 0 59 0 0 24 0 0 6 % L
% Met: 0 0 71 0 0 0 0 0 42 6 0 0 0 0 0 % M
% Asn: 6 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 77 36 0 % P
% Gln: 0 0 0 0 0 6 0 0 0 0 12 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 0 0 0 0 0 6 0 % R
% Ser: 0 65 0 6 0 0 0 0 0 0 71 0 6 18 0 % S
% Thr: 0 12 0 0 0 0 0 0 0 0 6 6 0 6 0 % T
% Val: 0 0 6 0 0 0 0 6 0 0 0 0 0 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 83 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _